Mathcomp Medical Systems bv develops a second-generation High-Intensity Focused Ultrasound (HIFU) system compatible for the Magnetic Resonance Imaging (MRI) environment for non-invasive cancer treatment by ablation. The multi-element piezo transducer and the microelectronics circuit for driving the output energy effectively across the target area, involves obeyance of physical laws: confined space availability, heat management, non-EMC emission and affordable manufacturing costs. Mathcomp Medical Systems was supported during its start-up phase by ESA's Technology Transfer Programme through its Business Incubation centre at ESTEC where it was hosted from August 2003 to December 2006.