Ariane 5 twice used its upper stage engine to finetune the orbit and release ATV to the trajectory leading towards the ISS; Ariane's mission was ended 1 hours and 7 minutes after take-off when ATV separated from upper stage.

After that ATV was switched on, the propulsion system was primed, solar arrays deployed and GPS system was turned on.

After about 10 days in orbit, ATV positioned itself 2000 km away from ISS to allow the completion of the STS-123 mission. Once visiting Space Shuttle departed and landed, departed Jules Verne from its parking orbit and approached ISS gruadually under the eye of the ATV-CC. The main objective of the Demo Days that followed was to demonstrate ATV's capability to execute the Collision Avoidance Manoeuvre (CAM), if a CAM were to be actually executed.

Demonstration Days: 29 - 31 March 2008

The first demonstration checked that Jules Verne ATV performed relative navigation with the ISS, using relative GPS successfully, and safely manoeuvred the ATV to the S₂ station keeping point, located 3.5 km behind the ISS, at the same orbital altitude. The escape manoeuvre – similar to the CAM – was tested and after that ATV commanded to return to S₂. ATV-CC analysed the flight results and gave the go ahead to conduct second demonstration.

The second Demonstration day tested ATV's close proximity manoeuvring and control, including testing contingency manoeuvres for ATV-CC and the ISS crew. ATV manoeuvred to within 11 metres of the docking port located on Zvezda, the Russian Service Module of the ISS. Finally the ISS crew issued the ESCAPE command and monitored when ATV returned to safe orbit with respect to the ISS Station keeping point S₄(19 m behind).

Docking: 3 April 2008

As Jules Verne got closer to actual docking, ATV-CC mission controllers directed the ATV in a step-by-step approach. This required authorisation from the Russian Mission Control Centre in Moscow (MCC-M), since ATV docks with Zvezda, the Russian segment of the ISS.

After slow and careful approach with Russian Kurs radar-based system, GPS, the Videometer and Telegoniometer (laser-pulsed instruments that calculate the distance and orientation to the ISS), under the eye of the ISS crew, ATV docked to Zvezda at 16:40 CET on 3 April 2008. The hooks attaching firmly the docking ports together were closed 17:14 CET: ATV was now permanently connected to Zvezda.

Undocking and re-entry: September 2008

Having been part of the ISS for six months, Jules Verne undocked from the International Space Station on 5 September 2008 at 23:29 CET. The ATV then embarked on the last leg of its journey in space, which ended with a controlled destructive re-entry into the Earth’s atmosphere on 29 September.

Following a final deorbit burn at 14:58 CET which slowed its velocity by 70 m/s, the ATV entered the upper atmosphere at an altitude of 120 km at 15:31 CET. It broke up at an altitude of 75 km with the remaining fragments falling into the Pacific some 12 minutes later.