The first main use of the Laboratory took place in 2007, and consisted of supporting science verification and mission simulation testing as well as late access flight preparation for the Foton M3 mission. During this major event the Laboratory demonstrated its capabilities to adapt to periods of peak activities. Some 35 life and physical science experiments had to be prepared and tested. The Laboratory accommodated more than 80 people, including scientists and technicians, giving them access to state-of-the-art facilities and equipment along with ESA in-house expertise.

Since then the Laboratory facilities have contributed to other flight projects. For instance, they were involved in the development and validation of disinfection procedures which were successfully applied during the Jules Verne ATV’s launch campaign in 2007-2008. The laboratory facilities are also supporting some activities of the MELiSSA project (Micro-Ecological Life Support System Alternative), which aims at, developing the technology required for a regenerative life support system to be used during future long term manned space missions.