The 15th International Symposium on Materials in the Space Environment (ISMSE) and 13th International Conference for Protection of Materials and Structures from the Space Environment represents one of the largest international conferences on materials in the space environment, with a heritage stretching back four decades. Jointly organised by ESA, French space agency CNES and French Aerospace Lab ONERA, together with industrial partner ITL, ISMSE-15 and ICPMSE-13 will take place on 18 - 23 September 2022 in the Naturalis Biodiversity Centre in the University city of Leiden in the Netherlands, European City of Science 2022.