Assessment of physical exercise benefits on brain health for long-duration spaceflights
An intriguing possibility, which has not been tested previously, is that the benefits of exercise for the brain can complement cognitive and psychological benefits provided by sleep. Exercise has several benefits for health and it is widely used as a prevention or treatment for many diverse diseases through enhancing the overall fitness or strengthening the cardio-vascular system. But scientific evidence suggests that exercise has also numerous benefits for mental and psychological health. Even though the long-term effects of exercise have been thoroughly investigated and are quite well understood, so far only few studies have looked at brain activity directly during or immediately after exercise. A thorough understanding of what happens precisely in the brain during exercise from a neurophysiologic point of view would enable us to design specific training schedules aimed at “manipulating” selectively brain activity in specific regions to achieve specific needed benefits.
A fascinating prospect is that some types of exercise could compensate for the lack of consolidated sleep during long-duration space missions enabling the preservation of optimal brain functioning. At the moment physical exercise is only obligatory to counter the effects of osteoporosis during weightlessness in space. However, using exercise in space may also lead to marked improvement of cognitive functions and psychological state, which are crucial during long-term flights. In order to tackle this question, we started collaboration with the research group of Prof. Vladyslav Vyazovskiy from the University of Oxford (UK) [http://www.vvlab.org/]. This group is set up to perform neurophysiological and behavioural experiments in laboratory rodents, using state-of-the-art electrophysiological techniques in freely-behaving mice and learning tasks. In the framework of our collaboration we are exploring the link between specific behaviours and associated activity of single neurons in the brain of awake mice and the amount and quality of subsequent sleep. The next step will be to understand how this knowledge can be transferred to humans and ultimately can be integrated into the astronauts’ training and daily activities to improve cognitive functions and psychological state during long-term space missions.