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The circadian process oscillates on a near 24 hours and defines the sleep inclination periods \", \"[2]\", \".\\nMost of the time, the circadian process is synchronized with the light/dark cycle. Regulated separately but in concomitance with the circadian process,\\nthe homeostatic process, represented by sleep pressure, builds up with the time spent awake. High sleep pressure markers can be observed during wakefulness, by a reinforcement of theta activity (5-8Hz),\\nand while asleep, by an increase of delta activity (0.5-4Hz), also called slow wave sleep \", \"[3]\", \".\"), mdx(\"p\", null, \"Slow wave sleep is thought to be the time when neurons perform cellular maintenance \", \"[4]\", \". Recently, it has been shown that similar local sleep episodes can be observed in awake rodents \", \"[5]\", \".\\nUsing scalp electroencephalography (EEG), local sleep-like events have also been studied in awake humans after a period of sleep deprivation \", \"[6]\", \".\"), mdx(\"p\", null, \"Experimental evidence indicates that astronauts tend to experience sleep deficiency on board of the international space station (ISS), at least until their circadian clock is realigned with the new environment \", \"[7]\", \".\"), mdx(\"p\", null, \"The aim of the project is to understand how sleep deficiency reported by most astronauts in space impacts sleep pressure by exploring local\\nelectrophysiological markers and how these markers are correlated to cognitive performances. First, we analysed human wake EEG data acquired on board the international space station (ISS) during the Neurospat experiment.\\nAllowing us to study local sleep-like events occurrences during wakefulness in 5 astronauts throughout their 6 months\\u2019 mission.\\nAs a second step, we compared our findings to waking EEG data recorded in 13 participants staying in isolation at the Antarctic Concordia Station during the 8 months of winter.\\nProviding valuable information on how confinement and space like environment impact sleep pressure and how physical activity can be an efficient countermeasure.\"), mdx(\"hr\", null), mdx(\"h2\", null, \"the project\"), mdx(\"p\", null, \"In the framework of an Ariadna project, the ACT and the Laboratory of Neurophysiology and Movement Biomechanics at the University of Brussels (ULB) are investigating\\n\", mdx(\"a\", {\n    parentName: \"p\",\n    \"href\": \"/gsp/ACT/doc/ARI/ARI%20Call%20doc/Study%20descriptions/ARI-study_17-9701.pdf\"\n  }, \"local sleep-like events during wakefulness and their relationship to decrease in alertness in five astronauts on the International Space Station\"), \".\"), mdx(\"p\", null, \"In the framework of MoU, the ACT and the Institute of Movement and Neurosciences at the German Sport University Cologne (DSHS) are investigating physical exercise,\\nmood and sleep pressure during isolation at the Antarctic Concordia Station.\"), mdx(\"hr\", null), mdx(\"h2\", null, \"literature\"), mdx(\"ol\", null, mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"G. Tononi and C. Cirelli, \\\"Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration\\u201D Neuron, vol. 81, no. 1, pp. 12\\u201334, 2013. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://doi.org/10.1016/j.neuron.2013.12.025\"\n  }, \"https://doi.org/10.1016/j.neuron.2013.12.025\")), mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"D.J. Dijk and C. A. Czeisler, \\u201CContribution of the Circadian Pacemaker and the Sleep Homeostat to Sleep Propensity, Sleep Structure, Electroencephalographic Slow Waves and Sleep Spindle Activity in Humans,\\u201D J. Neurosci., vol. 15, no. May, 1995. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://dx.doi.org/10.1523%2FJNEUROSCI.15-05-03526.1995\"\n  }, \"https://dx.doi.org/10.1523%2FJNEUROSCI.15-05-03526.1995\")), mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"A. A. Borb\\xE9ly, S. Daan, A. Wirz-Justice, and T. Deboer, \\u201CThe two-process model of sleep regulation: A reappraisal\\u201D J. Sleep Res., vol. 25, no. 2, pp. 131\\u2013143, 2016. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://doi.org/10.1111/jsr.12371\"\n  }, \"https://doi.org/10.1111/jsr.12371\")), mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"V. V. Vyazovskiy and K. D. Harris, \\u201CSleep and the single neuron: the role of global slow oscillations in individual cell rest\\u201D Nat. Neurosci., vol. 14, no. June, pp. 443\\u2013451, 2013. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972489/\"\n  }, \"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972489/\")), mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"V. V. Vyazovskiy, U. Olcese, E. C. Hanlon, Y. Nir, C. Cirelli, and G. Tononi, \\u201CLocal sleep in awake rats\\u201D Nature, vol. 472, no. 7344, pp. 443\\u20137, 2011. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085007/\"\n  }, \"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085007/\")), mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"C.S. Hung et al., \\u201CLocal Experience-Dependent Changes in the Wake EEG after Prolonged Wakefulness\\u201D Sleep, vol. 36, no. 1, pp. 59\\u201372, 2013. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://dx.doi.org/10.5665%2Fsleep.2302\"\n  }, \"https://dx.doi.org/10.5665%2Fsleep.2302\")), mdx(\"li\", {\n    parentName: \"ol\"\n  }, \"E. E. Flynn-evans, L. K. Barger, A. A. Kubey, J. P. Sullivan, and C. A. Czeisler, \\u201CCircadian misalignment affects sleep and medication use before and during space flight\\u201D NPJ Microgravity, vol. 2, no. 2016, pp. 1\\u20136, 2016. \", mdx(\"a\", {\n    parentName: \"li\",\n    \"href\": \"https://www.nature.com/articles/npjmgrav201519\"\n  }, \"https://www.nature.com/articles/npjmgrav201519\"))));\n}\n;\nMDXContent.isMDXComponent = true;","fields":{"slug":"/projects/local_sleep/"},"frontmatter":{"title":"Local sleep episodes during wakefulness ","pagetype":null,"categories":["bng"],"author":null,"institution":null,"banner":null,"banner_caption":null,"headline":"Experimental evidence indicates that astronauts tend to experience sleep deficiency on board of the international space station (ISS), at least until their circadian clock is realigned with the new environment.\nThe aim of our project is to understand how sleep deficiency reported by most astronauts in space impacts local sleep episodes.\n","image_src":"/images/projects/Local_sleep.jpg","date":"2017-09-01T00:00:00.000Z","time":null,"outcome":[{"actCategory":"Bioengineering","authors":"Petit, Gaetan and Abeln, Vera and Summerer, Leopold and Schneider, Stefan and Huber, Reto","booktitle":null,"editor":null,"institution":null,"journal":"bioRxiv","key":"BNG-art-16","kind":"Peer reviewed article","month":null,"number":null,"organization":null,"pages":"516-567","publisher":"Cold Spring Harbor Laboratory","quarter":"2019-1","rawBibtex":"@article{Petit2019Electrophysiological,\n\tauthor = {Petit, Gaetan and Abeln, Vera and Summerer, Leopold and Schneider, Stefan and Huber, Reto},\n\tjournal = {bioRxiv},\n\tyear = {2019},\n\tpages = {516--567},\n\tpublisher = {Cold Spring Harbor Laboratory},\n\ttitle = {Electrophysiological measures of sleep pressure during wakefulness in the course of isolation at the {Concordia} {Antarctica} station and physical activity as a countermeasure},\n}\n\n","title":"Electrophysiological measures of sleep pressure during wakefulness in the course of isolation at the Concordia Antarctica station and physical activity as a countermeasure","type":"article","url":"http://dx.doi.org/10.1101/516567","volume":null,"year":"2019"},{"actCategory":"Bioengineering","authors":"Petit, Gaetan and Cebolla, Ana Maria and Fattinger, Sara and Petieau, Mathieu and Summerer, Leopold and Cheron, Guy and Huber, Reto","booktitle":null,"editor":null,"institution":null,"journal":"NPJ microgravity","key":"BNG-art-17","kind":"Peer reviewed article","month":null,"number":null,"organization":null,"pages":"10","publisher":"Nature Publishing Group","quarter":"2019-2","rawBibtex":"@article{Petit2019Local,\n\tauthor = {Petit, Gaetan and Cebolla, Ana Maria and Fattinger, Sara and Petieau, Mathieu and Summerer, Leopold and Cheron, Guy and Huber, Reto},\n\tjournal = {NPJ microgravity},\n\tyear = {2019},\n\tpages = {10},\n\tpublisher = {Nature Publishing Group},\n\ttitle = {Local sleep-like events during wakefulness and their relationship to decreased alertness in astronauts on {ISS}},\n}\n\n","title":"Local sleep-like events during wakefulness and their relationship to decreased alertness in astronauts on ISS","type":"article","url":"https://www.nature.com/articles/s41526-019-0069-0","volume":null,"year":"2019"}]}}},"pageContext":{"id":"851b26af-3300-5953-94fc-006bef19f5af"}},
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