ESA's Phi-Lab Switzerland at the European Space Deep-Tech Innovation Centre (ESDI) in Villegen, aspires to transform breakthrough science into real-world solutions. The approach based on use-inspired research, combined with deep-tech competence in our ecosystem, promises that developments are scientifically excellent, commercially relevant and have potential market impact. We expect that this accelerates progress from laboratory demonstrations to market-ready products that meet the demanding standards of space, but also terrestrial applications.