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The Mars500 study is set to take place in a special facility at the Russian Institute of Biomedical Problems in Moscow

Paolo Nespoli trains in the Soyuz simulator at Star City

Soyuz system training for Paolo Nespoli at Star City

Soyuz system training for Paolo Nespoli at Star City

André Kuipers trains in the Soyuz simulator at Star City

Classroom lessons are also part of the astronaut training at Star City

André Kuipers climbs out of the Soyuz simulator at Star City

Detail of the Russian Sokol spacesuit

View of a training hall at Star City

Frank De Winne trains with his crew in the Soyuz simulator in Star City

De Winne trains at Star City for his flight on the Soyuz spacecraft

ISS viewed from Endeavour following undocking on 28 November 2008

ISS viewed from Endeavour following undocking on 28 November 2008

A view of one of the trusses on the International Space Station

The final four European participants for the 105-day simulated Mars mission

Interior view of the Italian-built Leonardo Multi-Purpose Logistics Module attached to the ISS

Interior view of the Italian-built Leonardo Multi-Purpose Logistics Module attached to the ISS

Cargo on Space Shuttle Endeavour includes some fresh fruit

A view of the Earth from the International Space Station

Space Station spacewalk during Shuttle mission STS-126

The STS-126 crew

Italian-built Multi-Purpose Logistics Module Leonardo en route to ISS with STS-126

NASA's advanced Resistive Exercise Device (aRED) for the ISS

Looking through the window in the Kibo laboratory of the ISS

Chamitoff works on a facility inside the Columbus laboratory

Installing a Geoflow experiment container in the Fluid Science Laboratory facility

Space Shuttle robotic arm against backdrop of Earth's horizon

ISS viewed from Space Shuttle Endeavour before docking on 16 November 2008

ISS viewed from Space Shuttle Endeavour before docking on 16 November 2008

Preparations for flight day 1 of the 49th ESA Parabolic Flight Campaign

Day 3 of the 49th ESA Parabolic Flight Campaign

Day 2 of the 49th ESA Parabolic Flight Campaign: The PK-4 plasma crystal experiment being prepared for flight to the ISS

Day 1 of the 49th ESA Parabolic Flight Campaign: A view inside the 'Zero G' cabin during the microgravity phase of a parabola

Day 1 of the 49th ESA Parabolic Flight Campaign: Parabolas

ESA astronaut Leopold Eyharts

The Canadian-built Dextre, also known as the Special Purpose Dextrous Manipulator

Space Station junction between the Harmony, Destiny and Kibo modules

A view from the International Space Station

Relocating an experiment rack inside the Kibo laboratory

NASA astronaut Greg Chamitoff in Columbus laboratory

NASA astronaut Greg Chamitoff uses the Microgravity Science Glovebox inside the Columbus laboratory

ESA astronaut Andre Kuipers tries out the Space Station bedroom mock-up at EAC

ESA astronaut Frank De Winne inspects the Space Station bedroom mock-up at EAC

ESA astronauts Kuipers and De Winne use the Microgravity Science Glovebox training model at EAC

ESA astronauts Frank De Winne and Andre Kuipers visit EAC for experiment training

ESA astronauts Frank De Winne and Andre Kuipers visit EAC for experiment training

ESA astronauts Frank De Winne and Andre Kuipers visit EAC for experiment training

ESA astronaut Frank De Winne during training for the Neurospat experiment at EAC

ESA astronaut Andre Kuipers during training for the Neurospat experiment at EAC

ESA astronauts Frank De Winne and Andre Kuipers during Neurospat training at EAC

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