* Exchange one member of the ISS permanent crew
ESA astronaut Thomas Reiter who was a member of ISS Expedition 13 crew from 6 July until 26 September 2006 and then became a member of the Expedition 14 crew, will be replaced as Expedition 14 Flight Engineer 2 by NASA astronaut Sunita Williams. As Reiter will be on the return journey with Fuglesang, this will be the first ISS flight that will have two ESA astronauts on board.
* Undertake a European experiment programme
During his mission, Fuglesang will be undertaking a number of European experiments in the areas of human physiology and radiation dosimetry including experiments with an educational application. One of the experiments that Fuglesang will perform, ALTEA, looks at the effects of cosmic radiation on brain function. This continues on from previous experiments such as the SilEye experiment on the Mir Space Station from 1995 to 1999 in which Fuglesang was involved as a scientist.
* Delivery of supplies in the Spacehab pressurised module
Spacehab is a pressurized aluminium module that travels in the Shuttle's cargo bay and is connected to the Shuttle's mid deck by a tunnel. It is similar in design to the European-developed Spacelab. Three previous ISS missions used the Spacehab Logistics Double Module (STS-96, STS-101 and STS-106), though for this fourth ISS mission utilising Spacehab, the Spacehab Logistics Single Module will be used. A Spacehab Single Module was used for the last time for the STS-95 mission, which included ESA astronaut Pedro Duque as a Mission Specialist. This module will will have the capacity to store and transport about 2.5 tonnes of supplies, equipment, and research payloads.
Among supplies being delivered are Service Module Debris Panels, which will increase ISS protection from potential impacts of micrometeorite debris. These will be temporarily stowed on the external surface of the ISS during the third EVA.