The Esperia mission was undertaken as an Italian Space Agency (ASI) flight opportunity, stemming from their agreement with NASA for the provision of 3 Multi-Purpose Logistics Modules. The cooperation with ESA led to the assignment of Paolo Nespoli to this flight and an additional agreement between ESA and ASI was signed to this effect.
A majority of Paolo’s tasks on the Esperia mission were tasks for Space Station 10A assembly mission. Paolo played a key role in the four spacewalks including the installation of Node 2. He was the key astronaut inside the Station and in direct contact with the spacewalking astronauts, coordinating their activities, as well as being involved in the spacewalk preparations such as configuring and testing spacesuits and tools, helping suit up and including airlock pressurisation.
The 16-day mission also relocated the Station's P6 truss section and deployed its solar arrays and heat dispersal radiator; deployed the heat dispersal radiators on the S1 truss; brought important supplies to the Station; exchange one ISS Expedition crewmember, and tested a new method of repairing damage to the Shuttle’s thermal protection system. As part of the Esperia mission Paolo also ran important experiments for the European scientific community as well as a number of educational activities.